Adacel Vaccination in Chennai

Indication and Usage –

• Adacel is a vaccine indicated for active booster immunization against tetanus, diphtheria and pertussis.
• Adacel is approved for use in individuals 10 through 64 years of age.

Dosage and Administration –

• Adacel is administered as a single 0.5 mL intramuscular injection.
• A first dose of Adacel is administered 5 years or more after the last dose of the Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) series or 5 years or more after a dose of Tetanus and Diphtheria Toxoids Adsorbed (Td).
• A second dose of Adacel may be administered 8 years or more after the first dose of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed (Tdap).

Contraindications –

• Hypersensitivity

1. A severe allergic reaction (eg, anaphylaxis) after a previous dose of any tetanus toxoid, diphtheria toxoid or pertussis containing vaccine or any other component of this vaccine is a contraindication to administration of Adacel
2. Because of uncertainty as to which component of the vaccine may be responsible, none of the components should be 3 administered. Alternatively, such individuals may be referred to an allergist for evaluation if further immunizations are to be considered.

• Encephalopathy

1. Encephalopathy (eg, coma, prolonged seizures, or decreased level of consciousness) within 7 days of a previous dose of a pertussis containing vaccine not attributable to another identifiable cause is a contraindication to administration of any pertussis containing vaccine, including Adacel.

Adverse reactions –

• Immune system disorders

Anaphylactic reaction, hypersensitivity reaction (angioedema, edema, rash, hypotension)

• Nervous system disorders

Paresthesia, hypoesthesia, Guillain-Barré syndrome, brachial neuritis, facial palsy, convulsion, syncope, myelitis

• Cardiac disorders

Myocarditis

• Skin and subcutaneous tissue disorders

Pruritus, urticaria

• Musculoskeletal and connective tissue disorders

Myositis, muscle spasm

• General disorders and administration site conditions

Large injection site reactions (>50 mm), extensive limb swelling from the injection site beyond one or both joints Injection site bruising, sterile abscess, Arthus hypersensitivity

Drug interactions and other interactions –

• When Adacel is administered concomitantly with other injectable vaccines or Tetanus Immune Globulin, they should be given with separate syringes and at different injection sites.
• Adacel should not be mixed with any other vaccine in the same syringe or vial.
• Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to vaccines.