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Synflorix Vaccination

2400.00
Availability: In Stock Category: Pneumococcal

Synflorix – GSK

Indication and Usage –

  • SYNFLORIX is indicated for active immunization of infants and children from 6 weeks up to 5 years of age against diseases caused by Streptococcus pneumoniae serotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, 23F and cross-reactive 19A
  • invasive disease (including sepsis, meningitis, bacteraemia pneumonia, pleural empyema and bacteraemia)
  • pneumonia
  • acute otitis media

Dosage and Administration –

  • Synflorix should be given by intramuscular injection. The preferred sites are anterolateral aspect of the thigh in infants or the deltoid muscle of the upper arm in children.
  • Infants from 6 weeks to 6 months of age:

Three-dose primary series

  • The recommended immunization series to ensure optimal protection consists of four doses, each of 0.5 mL.

Dose

Dose 1

Dose 2

Dose 3

Dose 4

Age at Dose

2 months

4 months

6 months

12-15 months

 

  • Vaccine Schedule for Infants from 2 to 6 months of age

Two-dose primary series alternatively,

Dose

Dose 2

Dose 3

Dose 4

Age at Dose

2 months

4 months

11-12 months

 

  • Previously unvaccinated older infants and children:

Age at First Dose

Total Number of 0.5 mL Doses

7-11 months of age

3

12 months to 5 years of age

2

 

Contraindications –

  • Synflorix should not be administered to subjects with known hypersensitivity to any component of the vaccine. For a complete listing, see the dosage forms, composition and packaging section of the product monograph.

Adverse reactions –

  • The most common adverse reactions observed after primary vaccination were redness at the injection site and irritability which occurred after approximately 41% and 55% of all doses respectively.
  • Following booster vaccination, the most common adverse reactions were pain at the injection site and irritability, which occurred at approximately 51% and 53% respectively.
  • The majority of these reactions were of mild to moderate severity and were not long lasting.

Drug interactions and other interactions –

  • Synflorix can be given concomitantly with any of the following
  1. monovalent or combination vaccines [including DTPa-HBV-IPV/Hib]:
  2. diphtheria-tetanus-acellular pertussis vaccine (DTPa),
  3. hepatitis B vaccine (HBV),
  4. inactivated polio vaccine (IPV),
  5. Haemophilus influenzae type b vaccine (Hib),
  6. measles-mumps-rubella vaccine (MMR),
  7. varicella vaccine,
  8. meningococcal
  9. rotavirus vaccine.
  • Different injectable vaccines should always be given at different injections sites.

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