Gardasil – MSD
Indication and Usage –
- Gardasil is a vaccine. Vaccination with Gardasil is intended to protect against diseases caused by Human Papillomavirus (HPV) types 6, 11, 16, and 18.
- These diseases include pre-cancerous lesions of the female genitals (cervix, vulva, and vagina); precancerous lesions of the anus and genital warts in males and females; cervical and anal cancers.
Dosage and Administration –
- If you are from 9 to and including 13 years of age
- Gardasil can be administered according to a 2-dose schedule: -
First injection: at chosen date –
Second injection: 6 months after first injection
If the second vaccine dose is administered earlier than 6 months after the first dose, a third dose should always be administered.
- If you are from 14 years of age
- Gardasil should be administered according to a 3-dose schedule: -
First injection: at chosen date -
Second injection: 2 months after first injection –
Third injection: 6 months after first injection
The second dose should be administered at least one month after the first dose and the third dose should be administered at least 3 months after the second dose. All three doses should be given within a 1-year period. Please speak to your doctor for more information.
- It is recommended that individuals who receive a first dose of Gardasil complete the vaccination course with Gardasil.
- Gardasil will be given as an injection through the skin into the muscle (preferably the muscle of the upper arm or thigh).
Contraindications –
- Hypersensitivity to the active substances or to any of the excipients of the vaccine including severe allergic reactions to yeast (a vaccine component).
- Individuals who develop symptoms indicative of hypersensitivity after receiving a dose of Gardasil should not receive further doses of Gardasil.
Adverse reactions –
The following side effects can be seen after the use of Gardasil:
- Very common(may affect more than 1 in 10 patients), side effects found at the injection site include: pain, swelling and redness. Headache was also seen.
- Common(may affect more than 1 in 100 patients), side effects found at the injection site include: bruising, itching, pain in extremity. Fever and nausea have also been reported.
- Rare(may affect less than 1 in 1,000 patients): hives (urticaria).
- Very rare(may affect less than 1 in 10,000 patients), difficulty breathing (bronchospasm) has been reported.
Drug interactions and other interactions –
- Gardasil may be administered concomitantly with HB VAX, Menactra, Adacel, absorbed Tdap and Repevax and Poliomyelitis.
- In clinical studies for girls and women (aged 16 to 26 years) of individuals used analgesics, anti-inflammatory drugs, antibiotics and vitamin preparations.
- The efficacy, immunogenicity and safety of the vaccine were not impacted by the use of these medications.
- In clinical studies, 50.2% of women (aged 16 to 45 years) who received Gardasil used hormonal contraceptives. Use of hormonal contraceptives did not appear to affect the immune responses to Gardasil.
The corticosteroids for all individuals were administered close to the time of administration of a dose of Gardasil. These medicines did not appear to affect the immune responses to Gardasil.
